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Is primary biliary cirrhosis an autoimmune disease? Primary biliary cholangitis is considered an autoimmune disease, which means your body's immune system is mistakenly attacking healthy cells and tissue. Researchers think a combination of genetic and environmental factors triggers the disease. It usually develops slowly.
What is the difference between PBC and autoimmune hepatitis? Autoimmune Hepatitis and Primary Biliary Cirrhosis Overlap Syndrome. In patients with AIH or PBC, the prevalence of overlap features is approximately 8% to 19%. When the disease has a sequential presentation, PBC is usually diagnosed first and AIH occurs later.
What are the stages of PBC? Liver biopsy also helps stage PBC, which has 4 histologic stages: Stage 1: Inflammation, abnormal connective tissue, or both, confined to the portal areas. Stage 2: Inflammation, fibrosis, or both, confined to the portal and periportal areas. Stage 3: Bridging fibrosis.
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